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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL1
All Species:
25.76
Human Site:
Y157
Identified Species:
43.59
UniProt:
Q00532
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00532
NP_004187.2
357
41671
Y157
L
L
A
G
P
S
D
Y
Y
T
D
Y
V
A
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100233
358
41783
Y158
L
L
T
G
P
S
D
Y
Y
T
D
Y
V
A
T
Dog
Lupus familis
XP_851358
367
42581
Y158
L
L
T
G
P
S
D
Y
Y
T
D
Y
V
A
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8CEQ0
352
41005
Y157
L
L
T
G
P
G
D
Y
Y
T
D
Y
V
A
T
Rat
Rattus norvegicus
Q66HE7
352
40881
Y157
L
L
T
G
P
G
D
Y
Y
T
D
Y
V
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
Y157
L
L
T
G
P
S
D
Y
Y
T
D
Y
V
A
T
Chicken
Gallus gallus
P13863
303
34670
I116
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
Frog
Xenopus laevis
P35567
302
34487
G115
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
Y157
I
L
T
G
P
C
D
Y
Y
T
D
C
V
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
N265
R
M
L
S
P
G
E
N
Y
T
D
Y
V
A
T
Honey Bee
Apis mellifera
XP_394980
385
44993
N180
R
M
L
S
P
G
E
N
Y
T
E
Y
V
A
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
E157
I
L
T
G
P
D
D
E
Y
T
D
Y
V
A
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
Y107
N
P
T
L
I
K
S
Y
L
Y
Q
I
L
H
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
Y107
D
L
H
M
I
K
T
Y
L
Y
Q
I
L
R
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.7
88.5
N.A.
88.8
88.2
N.A.
86.5
37.8
36.9
77
N.A.
43.1
53.2
N.A.
59.5
Protein Similarity:
100
N.A.
99.1
92.6
N.A.
92.7
93
N.A.
92.7
52.3
54.6
87.9
N.A.
54.6
69.6
N.A.
73
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
86.6
86.6
N.A.
93.3
6.6
6.6
73.3
N.A.
53.3
46.6
N.A.
73.3
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
86.6
86.6
N.A.
93.3
13.3
13.3
80
N.A.
66.6
66.6
N.A.
80
Percent
Protein Identity:
N.A.
34.4
N.A.
33
N.A.
N.A.
Protein Similarity:
N.A.
54.3
N.A.
54.6
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
0
0
0
72
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
8
15
0
0
0
% C
% Asp:
8
0
0
0
0
8
58
0
0
0
65
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
15
8
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% F
% Gly:
0
0
0
58
0
29
8
8
0
0
0
0
0
0
15
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
8
8
8
0
% H
% Ile:
15
0
0
8
22
0
0
8
8
0
0
15
0
0
0
% I
% Lys:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% K
% Leu:
50
72
15
8
8
8
0
0
15
0
0
0
15
0
0
% L
% Met:
0
15
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
72
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
8
0
8
8
0
0
0
15
0
0
0
0
% Q
% Arg:
15
0
0
0
0
0
0
0
0
0
0
0
0
15
15
% R
% Ser:
0
0
0
15
0
29
8
0
0
0
0
0
8
8
0
% S
% Thr:
0
0
58
0
0
0
8
0
0
72
0
0
0
0
72
% T
% Val:
0
0
0
0
0
0
0
0
8
8
0
0
72
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
8
0
0
0
0
65
72
15
0
65
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _